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Ultrasonic Irradiation: Synthesis,Characterization,and Preliminary Antimicrobial Activity of Novel Series of 4,6-Disubstituted-1,3,5-triazine Containing Hydrazone Derivatives
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نویسنده
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al-rasheed h.h. ,al alshaikh m. ,khaled j.m. ,alharbi n.s. ,el-faham a.
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منبع
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journal of chemistry - 2016 - دوره : 2016 - شماره : 0
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چکیده
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Novel series of 4,6-disubstituted-1,3,5-triazines containing hydrazone derivatives were synthesized employing ultrasonic irradiation and conventional heating. the ultrasonication gave the target products in higher yields and purity in shorter reaction time compared with the conventional method. ir,nmr (h 1 and c 13),elemental analysis,and lc-ms confirmed the structures of the new products. the antimicrobial and antifungal activities were evaluated for all the prepared compounds against some selected gram-positive and gram-negative bacterial strains. the results showed that only two compounds 7i (pyridine derivative) and 7k (4-chlorobenzaldehyde derivative) displayed biological activity against some gram-positive and gram-negative bacteria,while the rest of the tested compounds did not display any antifungal activity. © 2016 hessa h. al-rasheed et al.
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آدرس
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department of chemistry,college of science,king saud university,p.o. box 2455,riyadh, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh, Saudi Arabia, department of botany and microbiology,college of science,king saud university,riyadh,saudi arabia,department of biotechnology and food technology,thamar university,dhamar, Yemen, department of botany and microbiology,college of science,king saud university,riyadh, Saudi Arabia, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh,saudi arabia,chemistry department,faculty of science,alexandria university,p.o. box 426,ibrahimia,alexandria, Egypt
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Authors
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