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Green Production of Indolylquinones,Derivatives of Perezone,and Related Molecules,Promising Antineoplastic Compounds
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نویسنده
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escobedo-gonzález r.g. ,pérez martínez h. ,nicolás-vázquez m.i. ,martínez j. ,gómez g. ,serrano j.n. ,carranza téllez v. ,vargas-requena c.l. ,miranda ruvalcaba r.
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منبع
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journal of chemistry - 2016 - دوره : 2016 - شماره : 0
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چکیده
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A green approach to produce the indolyl derivatives from four natural quinones (perezone,isoperezone,menadione,and plumbagin) was performed; in this regard,a comparative study was accomplished among the typical mantle heating and three nonconventional activating modes of reaction (microwave,near-infrared,and high speed ball milling or tribochemical),under solventless conditions and using bentonitic clay as a catalyst. in addition,the tribochemical production of isoperezone from perezone is also commented on. it is also worth noting that the cytotoxicity of the synthesized indolylquinones in human breast cancer cell was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,with the 3-indolylisoperezone being the most active. the structural attribution of the target molecules was performed by typical spectroscopic procedures; moreover,the experimental and computed 1h and 13c nmr chemical shifts data,with previous acquisition of the corresponding minimum energetic structures,were in good agreement. © 2016 rené gerardo escobedo-gonzález et al.
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آدرس
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departamento de ciencias químicas,facultad de estudios superiores cuautitlán,universidad nacional autónoma de méxico,cuautitlán izcalli,mex, Mexico, departamento de ciencias químicas,facultad de estudios superiores cuautitlán,universidad nacional autónoma de méxico,cuautitlán izcalli,mex, Mexico, departamento de ciencias químicas,facultad de estudios superiores cuautitlán,universidad nacional autónoma de méxico,cuautitlán izcalli,mex, Mexico, facultad de ciencias químicas,posgrado en ciencias en ingeniería química,universidad autónoma de san luis potosí,san luis potosí,slp, Mexico, escuela nacional de ciencias biológicas,instituto politécnico nacional,casco de santo tomas,ciudad de méxico,cdmx, Mexico, escuela nacional de ciencias biológicas,instituto politécnico nacional,casco de santo tomas,ciudad de méxico,cdmx, Mexico, laboratorio de espectrometría de masas,centro de química,icuap,benemérita universidad autónoma de puebla,puebla,pue, Mexico, laboratorio de biotecnología,instituto de ciencias biomédicas,universidad autónoma de ciudad juárez,anillo envolvente del pronaf s/n,ciudad juárez,chih, Mexico, departamento de ciencias químicas,facultad de estudios superiores cuautitlán,universidad nacional autónoma de méxico,cuautitlán izcalli,mex, Mexico
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Authors
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