Enaminonitrile as building block in heterocyclic synthesis: Synthesis of novel 4H -Furo[2,3- d ][1,3]oxazin-4-one and Furo[2,3- d ]pyrimidin-4 (3H) -one Derivatives

2-amino-4,5-diphenylfuran-3-carbonitrile 1 was utilized as building block for the construction of new furo[2,3-d]pyrimidin-4(3h)-one derivative 2 and 4h-furo[2,3-d][1,3]oxazin-4-one derivative 3 via treatment with acetic anhydride and benzoyl chloride,respectively. the 4h-furo[2,3-d][1,3]oxazin-4-one derivative 3 was transformed into novel furo[2,3-d]pyrimidin-4(3h)-ones 4-8,tetrazolylfuran derivative 10,and furo[3,2-d]imadazolone derivative 11 via reaction with various nitrogen nucleophiles. the structure features of the synthesized compounds were established from their spectral and elemental analyses. © 2017 manal m. el-shahawi and ahmed k. el-ziaty.