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   One-Pot Multicomponent Synthesis of Thiourea Derivatives in Cyclotriphosphazenes Moieties  
   
نویسنده ngaini z. ,wan zulkiplee w.s.h. ,abd halim a.n.
منبع journal of chemistry - 2017 - دوره : 2017 - شماره : 0
چکیده    In this study,hexasubstituted thiourea was carried out via reaction of isothiocyanato cyclophosphazene intermediates with a series of aromatics amines and amino acids in a one-pot reaction system. the reaction was not as straightforward as typical thiourea synthesis. six unexpected thiourea derivatives 3a-f were formed in the presence of cyclotriphosphazene moieties in good yields (53-82%). the structures of 3a-f were characterized by elemental analysis and ftir,1h,13c,and 31p nmr spectroscopies. the occurrence of reverse thioureas formation in a one-pot reaction system is discussed. the possible binding interaction of the synthesised thiourea 3a-b in comparison to the predicted phenyl thiourea 5a-b and the targeted 4a with enzyme enoyl acp reductase (fabi) is also discussed. molecular docking of the targeted hexasubstituted thiourea 4a is able to give higher binding affinity of -7.5 kcal/mol compared to 5a-b (-5.9 kcal/mol and -6.3 kcal/mol) and thiourea 3a-b (-4.5 kcal/mol and -4.7 kcal/mol). © 2017 zainab ngaini et al.
آدرس faculty of resource science and technology,universiti malaysia sarawak,kota samarahan,sarawak, Malaysia, centre for pre-university studies,universiti malaysia sarawak,kota samarahan,sarawak, Malaysia, faculty of resource science and technology,universiti malaysia sarawak,kota samarahan,sarawak, Malaysia
 
     
   
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