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Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives
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نویسنده
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pivazyan v.a. ,ghazaryan e.a. ,shainova r.s. ,tamazyan r.a. ,ayvazyan a.g. ,yengoyan a.p.
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منبع
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journal of chemistry - 2017 - دوره : 2017 - شماره : 0
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چکیده
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A convenient,accessible,and high yield method for preparing of 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1h)-one (1) by treatment of acetoacetic acid ethyl ester with thiourea in sodium methylate was developed. the alkylation of the latter with 3-chloro-pentane-2,4-dione and further regioselective cyclization of intermediate compound (2) in high yield afforded 2-acetyl-3,7-dimethyl-5h-thiazolo[3,2-a]pyrimidin-5-one (3). the halogenation and some transformations of synthesized thiazolo[3,2-a]pyrimidine (3) due to its ketone group were carried out to obtain the corresponding carboxamide,carbothioamide,sulfonohydrazide,and oxime and its alkylated derivatives (5). at preliminary biological studies the synthesized compounds have shown growth stimulant properties. the activity of four of them was higher than 70%,compared with heteroauxin. copyright � 2017 vergush a. pivazyan et al.
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آدرس
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national agrarian university of armenia,74 teryan str.,yerevan, Armenia, armenian-russian (slavonic) state university,123 h. emin str.,yerevan, Armenia, national agrarian university of armenia,74 teryan str.,yerevan,armenia,armenian-russian (slavonic) state university,123 h. emin str.,yerevan, Armenia, stc opc molecule structure research center of nas ra,26 azatutyan av.,yerevan, Armenia, stc opc molecule structure research center of nas ra,26 azatutyan av.,yerevan, Armenia, national agrarian university of armenia,74 teryan str.,yerevan,armenia,armenian-russian (slavonic) state university,123 h. emin str.,yerevan, Armenia
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Authors
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