Synthesis of New (E) -2-(1 H -Indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles via Microwave-Assisted Knoevenagel Condensation

Given the broad spectrum of biological uses of heteroaryl-acrylonitrile derivatives,it is necessary to find simple methods to synthesize and diversify this family of compounds. we report a stereoselective synthesis of a series of new (e)-2-(1h-indole-3-ylcarbonyl)-3-heteroaryl-acrylonitriles (3a-3i) obtained from 3-(cyanoacetyl)indole and heteroaryl-aldehydes under microwave-assisted knoevenagel reaction at 300 w of potency and 100°c. the desired derivatives (3a-3i) were obtained with variable yields (30-94%) and time reactions (8-90 min). all the heteroaryl-acrylonitriles were characterized by physicoanalytical techniques such ir,1h,13c nmr,and electrospray mass spectrometry. © 2017 adriana v. treuer et al.