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Synthesis,Characterization,and Antibacterial Activity of Diethyl 1-((4-Methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1 H -1,2,3-triazole-4,5-dicarboxylate
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نویسنده
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boukhssas s. ,aouine y. ,faraj h. ,alami a. ,el hallaoui a. ,bekkari h.
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منبع
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journal of chemistry - 2017 - دوره : 2017 - شماره : 0
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چکیده
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The compound,diethyl 1-((4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1h-1,2,3-triazole-4,5-dicarboxylate 2,was synthesized in high yield,through 1,3-dipolar cycloaddition reaction of 4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole and diethyl but-2-ynedioate in the absence of a solvent. the structure of the synthesized compound was established on the basis of nmr spectroscopy (1h,13c),x-ray crystallography,and ms data. the prepared compound was also tested in vitro for its antibacterial activity against gram-positive bacteria (staphylococcus aureus) and gram-negative bacteria (escherichia coli). the calculation of mbc/mic ratio showed that this triazole derivative 2 had a bactericidal effect on the two strains tested. © 2017 s. boukhssas et al.
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آدرس
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doctoral training 'bioactive molecules,health and biotechnology',center of doctoral studies 'sciences and technology',lco,faculty of sciences dhar mahraz,sidi mohamed ben abdellah university,fez, Morocco, organic chemistry laboratory (lco),faculty of sciences dhar mahraz,sidi mohamed ben abdellah university,fez, Morocco, organic chemistry laboratory (lco),faculty of sciences dhar mahraz,sidi mohamed ben abdellah university,fez, Morocco, organic chemistry laboratory (lco),faculty of sciences dhar mahraz,sidi mohamed ben abdellah university,fez, Morocco, organic chemistry laboratory (lco),faculty of sciences dhar mahraz,sidi mohamed ben abdellah university,fez, Morocco, laboratory of biotechnologies (lb),faculty of sciences dhar mahraz,sidi mohamed ben abdellah university,fez, Morocco
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Authors
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