Investigation of antimicrobial,antioxidant,and DNA binding studies of bioactive Cu(II),Zn(II),Co(II),and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

A new pyrimidine based schiff base ligand (hl) and its four complexes of type [mloac]·nh2o (cu(ii),1; zn(ii),2; co(ii),3; and ni(ii),4) have been synthesized and characterized by elemental analysis,ms,1h-nmr,ft-ir,uv-visible,and esr techniques. the electronic and esr spectral data suggested that complexes 1-4 possess square planar geometry. antimicrobial activities of hl and complexes 1-4 were tested against four bacteria (staphylococcus aureus,staphylococcus pneumonia,salmonella enterica typhi,and haemophilus influenzae) and two fungal strains (aspergillus flavus and aspergillus niger). these results show that complexes 1-4 have good antimicrobial activity compared to hl. the dna cleavage activity of hl and complexes 1-4 was monitored by the agarose gel electrophoresis method. the antioxidant property of the prepared compounds was assessed by using 2,2′-diphenyl-1-picrylhydrazyl (dpph) free radical scavenging method. dna binding properties of hl and complexes 1-4 have been investigated by electronic absorption technique and viscometric measurements. © 2017 shahul hameed sukkur saleem et al.