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α -Amylase and α -Glucosidase Inhibitory Activities of Phenolic Extracts from Eucalyptus grandis × E. Urophylla Bark
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نویسنده
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jiang p. ,xiong j. ,wang f. ,grace m.h. ,lila m.a. ,xu r.
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منبع
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journal of chemistry - 2017 - دوره : 2017 - شماره : 0
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چکیده
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This study evaluated the inhibitory effects of different extracts and fractions from eucalyptus. grandis × urophylla bark (eb) against α-glucosidase and α-amylase enzyme activities. the ethyl acetate extract (eb-e) showed the highest activity among others. seven fractions were derived from eb-e; among them eb-e-7 showed the highest significant inhibition of both enzymes,with ic50 of 1.40±0.18 and 1.72±0.12 μg/ml,respectively. eb-e and its active fraction eb-e-7 showed highest contents of total phenolics: 178.79±4.68 and 920.4±5.46 mg gaeag-1,respectively. hplc-ms analysis of eb-e-7 revealed the presence of ellagic acid,quercetin-glucuronide,quercetin-3-α-rhamnopyranoside,and ellagic acid rhamnoside as major compounds,together with smaller concentrations of myricetin-rhamnoside,isorhamnetin-hexoside,myricetin-3-α-arabinofuranoside,and isorhamnetin. therefore,the phenolic compounds from eucalyptus grandis × e. urograndis bark potently inhibited α-amylase and α-glucosidase activity,having potential in prevention of hyperglycemia. © 2017 ping jiang et al.
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آدرس
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college of chemical engineering,jiangsu key lab of biomass-based green fuels and chemicals,nanjing forestry university,nanjing,jiangsu, China, college of chemical engineering,jiangsu key lab of biomass-based green fuels and chemicals,nanjing forestry university,nanjing,jiangsu, China, college of chemical engineering,jiangsu key lab of biomass-based green fuels and chemicals,nanjing forestry university,nanjing,jiangsu, China, plants for human health institute,department of food bioprocessing and nutritional sciences,north carolina state university,north carolina research campus,kannapolis,nc, United States, plants for human health institute,department of food bioprocessing and nutritional sciences,north carolina state university,north carolina research campus,kannapolis,nc, United States, college of chemical engineering,jiangsu key lab of biomass-based green fuels and chemicals,nanjing forestry university,nanjing,jiangsu, China
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Authors
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