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Synthesis,Characterization,and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives
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نویسنده
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sharma a. ,jad y. ,siddiqui m.r.h. ,de la torre b.g. ,albericio f. ,el-faham a.
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منبع
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journal of chemistry - 2017 - دوره : 2017 - شماره : 0
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چکیده
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1,3,5-triazines and pyrimidine-2,4,6-triones belong to that class of compounds which are well known in literature for possessing wide range of biological activities. here,we report a new family of compounds that encompasses these two structures. the union of both heterocycles was carried out through a hydrazone moiety incorporated into an acetyl group at the position 5 of 1,3-dimethyl pyrimidine derivative. the synthetic strategy adopted allowed the preparation of the target compounds with excellent yields and good purities. the synthesized compounds were well characterized by nmr (1h and 13c),hrms,and elemental analysis. furthermore,the tautomerism of enhydrazine versus hydrazone has also been studied. © 2017 anamika sharma et al.
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آدرس
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school of health sciences,university of kwazulu-natal,durban, South Africa, school of health sciences,university of kwazulu-natal,durban, South Africa, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh, Saudi Arabia, school of laboratory medicine and medical sciences,university of kwazulu-natal,durban,south africa,department of organic chemistry,university of barcelona,barcelona, Spain, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh,saudi arabia,department of organic chemistry,university of barcelona,barcelona,spain,ciber-bbn,networking centre on bioengineering,biomaterials and nanomedicine,barcelona science park,barcelona,spain,school of chemistry and physics,university of kwazulu-natal,durban, South Africa, department of chemistry,college of science,king saud university,p.o. box 2455,riyadh,saudi arabia,chemistry department,faculty of science,alexandria university,p.o. box 426,ibrahimia,alexandria, Egypt
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Authors
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