Palladium on Layered Double Hydroxide: A Heterogeneous System for the Enol Phosphate Carbon-Oxygen Bond Activation in Aqueous Media

In this work,a new catalytic approach for the c-o activation of enol phosphates based on a palladium supported on layered double hydroxide was developed. in this case,two different ketene aminal phosphates were used as models to study the synthesis of α-phenyl enecarbamates n-boc/cbz under the suzuki-miyaura conditions. the use of an ortho-bromoaniline as precursor allowed the synthesis of the 2-phenyl indole through an arylation/heck cyclization. catalyst reusability enabled the synthesis of the heterocycle in moderate yields for four consecutive runs. � 2017 jaqueline d. senra et al.