Prognostic and therapeutic role of nuclear factor-kappa B (NF-kappaB) in breast cancer.

Nuclear factor- kappa b (nf-kappab) is an essential transcription factor that not only modulates cellular responses to stress but also plays a pivotal role in inflammation,immunity,cell cycle growth and survival. nf-kappab-regulated genes have been documented to be involved in cellular proliferation and invasion along with tumour related angiogenesis and lymphangiogenesis. dysregulation of nf-kappab associated pathways are seen in multiple malignancies. its constitutive activation in the clinically aggressive and prognostically poor er-negative,her2-neu positive and inflammatory breast cancer could formulate the basis for its evolution as a potential prognostic and therapeutic target.