RELATIONSHIP OF ADIPONECTIN LEVEL WITH LIPID PROFILE IN TYPE-2 DIABETIC MEN WITH CORONARY HEART DISEASE

Background: cerebro-vascular disease is a commonest long term complication of type-2 diabetes mellitus. the study was done to determine concentration of serum adiponectin and lipid profile in type-2 diabetic men with coronary heart disease (chd) in the region of khyber pakhtunkhwa (kpk),and to find possible relationship between them.methods: this was a cross-sectional study comprising of randomly selected thirty six healthy adult males and thirty six type-2 diabetic males with coronary heart disease. their fasting blood samples were analysed for serum adiponectin,fasting blood glucose,glycosylated haemoglobin and lipid profile which included total cholesterol (t-c),triglycerides (tg),high-density lipoprotein cholesterol (hdl-c) and low-density lipoprotein cholesterol (ldl-c). the relationship of adiponectin with other variables in type-2 diabetic men with coronary heart disease was determined with pearson correlations coefficient (r).results: type-2 diabetic males with coronary heart disease when compared to healthy males showed significantly low levels of serum adiponectin (p=<0.001) and hdl-c (p=<0.001) and significantly high level of fbg (p=<0.001),hbalc (p=<0.001),tc (p=<0.05),tg (p=<0.05) and ldl-c (p=<0.05). serum adiponectin level showed a significant negative correlation with fbg (r = -0.332; p= 0.04),hbalc (r = -0.818; p=<0.01) and tg (r = -0.640; p=<0.01) in type-2 diabetic men with coronary heart disease. adiponectin showed a significant positive association with hdl-c in controls (r = 0.948; p=<0.01) and patients of type-2 diabetes with chd (r = 0.650; p=<0.01).conclusion: serum adiponectin concentration is markedly decreased in patients of type-2 diabetes with coronary heart disease. hypoadiponectinemia is related with deranged lipid profile,i.e.,high tg and low hdl-c levels in type-2 diabetic men with chd. moreover,adiponectin is associated positively with hdl-c and negatively with hbalc and tg levels in the studied population.