EFFECT OF INTRAOPERATIVE MITOMYCIN-C APPLICATION IN OUTCOME OF EXTERNAL DACRYOCYSTORHINOSTOMY

Background: patients develop postoperative fibrosis at the site of operation after dacryocystorhinostomy (dcr) which results in impairment of the osteum patency. this quasi-experimental study was undertaken to determine the role of intraoperative mitomycin c (mmc) application in maintaining postoperative patency of the osteum.methodology: the present study was conducted at the eye department of ayub medical college,abbottabad on patients in whom routine dcr was indicated. subjects were divided into mitomycin c (test) and non mitomycin c (control) groups. in test group,mitomycin c was applied to the anastomosed flaps and osteotomy site for 30 minutes. postoperative patients were followed for up to 6 months and outcome of patency was documented.results: a.total of 73 patients were included,divided into test (30) and control (43) groups. an overall success rate of 86.3% was obtained for patent ostia; this was based on 96.67% success in test group compared to 79.1% in the control group (p=0.031).conclusion: intraoperative application of mitomycin-c significantly improves the success rate in external dacryocystorhinostomy.