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Urinary metabolomics on the biochemical profiles in diet-induced hyperlipidemia rat using ultraperformance liquid chromatography coupled with quadrupole time-of-flight SYNAPT high-definition mass spectrometry
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نویسنده
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miao h. ,chen h. ,zhang x. ,yin l. ,chen d.-q. ,cheng x.-l. ,bai x. ,wei f.
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منبع
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journal of analytical methods in chemistry - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Ultraperformance liquid chromatography coupled with quadrupole time-of-flight synapt high-definition mass spectrometry metabolomics was used to characterize the urinary metabolic profiling of diet-induced hyperlipidaemia in a rat model. analysis was done by orthogonal partial least squares discriminant analysis,correlation analysis,heat map analysis,and kegg pathways analysis. potential biomarkers were chosen by s-plot and were identified by accurate mass,isotopic pattern,and ms/ms fragments information. significant differences in fatty acid,amino acid,nucleoside,and bile acid were observed,indicating the perturbations of fatty acid,amino acid,nucleoside,and bile acid metabolisms in diet-induced hyperlipidaemia rats. this study provides further insight into the metabolic profiling across a wide range of biochemical pathways in response to diet-induced hyperlipidaemia. © 2014 hua miao et al.
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آدرس
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department of physical education,northwest university,no. 229 taibai north road,xi'an, China, department of traditional chinese medicine,college of life sciences,northwest university,no. 229 taibai north road,xi'an, China, department of physical education,northwest university,no. 229 taibai north road,xi'an, China, department of traditional chinese medicine,college of life sciences,northwest university,no. 229 taibai north road,xi'an, China, department of traditional chinese medicine,college of life sciences,northwest university,no. 229 taibai north road,xi'an, China, national institutes for food and drug control,state food and drug administration,2 tiantan xili, China, solution centre,waters technologies (shanghai) ltd.,no. 1000 jinhai road, China, national institutes for food and drug control,state food and drug administration,2 tiantan xili, China
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Authors
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