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Determination of matrine in rat plasma after oral administration of novel korean herbal medicine KIOM-MA128 and application of PK
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نویسنده
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back h.-m. ,song b. ,chae j.-w. ,yun h.-y. ,ma j.y. ,kwon k.-i.
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منبع
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journal of analytical methods in chemistry - 2015 - دوره : 2015 - شماره : 0
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چکیده
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Kiom-ma128 is a novel korean herbal medicine with antiatopic,anti-inflammatory,and antiasthmatic effects. matrine is thought to be a potential chemical marker of kiom-ma128,but pharmacokinetic studies on kiom-ma128 had not been performed. this study describes a simple and rapid method using high-performance liquid chromatography-tandem mass spectrometry (hplc-ms/ms) to determine the concentration of matrine in rats plasma after administration of kiom-ma128. the isocratic mobile phase consisted of methanol and distilled water,and the flow rate was 0.15 ml/min. the accuracy and precision of the assay,as well as stability tests,were performed in accordance with fda regulations for the validation of bioanalytical methods. the half-life and t max of matrine after administration of kiom-ma128 were 4.29 ± 2.20 h and 1.8 ± 1.23 h,respectively. c max and auc inf of matrine after administration of kiom-ma128 at 4 g/kg and 8 g/kg were 595.10 ± 182.91 ng/ml,5336.77 ± 1503.84 ng/ml·h and 850.46 ± 120 ng/ml,9583.10 ± 888.92 ng/ml·h,respectively. the validated method was successfully applied to a pharmacokinetic study in rats after oral administration of kiom-ma128. © 2015 hyun-moon back et al.
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آدرس
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college of pharmacy,chungnam national university, South Korea, college of pharmacy,chungnam national university, South Korea, college of pharmacy,chungnam national university, South Korea, college of pharmacy,chungnam national university, South Korea, herbal medicine improvement research center,korea institute of oriental medicine, South Korea, college of pharmacy,chungnam national university, South Korea
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Authors
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