Eicosanoid production following one bout of exercise in middle-aged African American pre- and stage 1 hypertensives

Endothelial dysfunction and a sedentary lifestyle may be involved in the development of hypertension which is proliferative among middle-aged african americans (aa). signaling molecules derived from the oxidation of 20-carbon fatty acid molecules known as eicosanoids influence vascular tone. the relationship between aerobic fitness and eicosanoid formation following exercise in middle-aged african american hypertensives is unknown. purpose. to determine the relationship between aerobic capacity and eicosanoid formation after a bout of moderate-intensity exercise in middle-aged aa hypertensives. methods. ten sedentary hypertensive aa underwent 50 min of aerobic exercise at 65% vo2max. urine was collected for 24 hr on two occasions,prior to testing and immediately following the bout of exercise. urinary metabolites of prostacyclin (6-keto pgf1α) and thromboxane (11-dtxb2) were measured during the day and night periods by high-performance liquid chromatography (hplc). results. 6-keto pgf1α levels significantly increased (p =.04) following the bout of exercise compared to the control day. there was a significant relationship (r =.49,p <.05) between 6-keto pgf1α levels and vo2max during the exercise day. conclusion. based on this preliminary study,there appears to be a relationship between aerobic capacity and exercise-induced 6-keto pgf1α production in middle-aged hypertensive aas. aas with lower vo2max had lower 6-keto pgf 1α formation. © 2011 sheara williamson et al.