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Association of leukocyte telomere length with fatigue in nondisabled older adults
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نویسنده
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bendix l. ,thinggaard m. ,kimura m. ,aviv a. ,christensen k. ,osler m. ,avlund k.
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منبع
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journal of aging research - 2014 - دوره : 2014 - شماره : 0
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چکیده
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Introduction. fatigue is often present in older adults with no identified underlying cause. the accruing burden of oxidative stress and inflammation might be underlying factors of fatigue. we therefore hypothesized that leukocyte telomere length (ltl) is relatively short in older adults who experience fatigue. materials and methods. we assessed 439 older nondisabled danish twins. ltl was measured using southern blots of terminal restriction fragments. fatigue was measured by the mob-t scale based on questions on whether the respondents felt fatigued after performing six mobility items. results. ltl was significantly associated with fatigue (p = 0.023),showing an increase of 0.038 kb/fatigue score unit. aging-related diseases and mental health did not explain the association,while lifestyle factors slightly attenuated the estimates. conclusion. our results support an association between ltl and fatigue. further studies are required to confirm this finding and the link of ltl with oxidative stress/inflammation over the life course. © 2014 laila bendix et al.
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آدرس
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danish aging research center,universities of southern denmark,aarhus,and copenhagen,denmark,section of social medicine,department of public health,university of copenhagen,p.o. box 2099, Denmark, danish aging research center,universities of southern denmark,aarhus,and copenhagen,denmark,epidemiology,institute of public health,university of southern denmark,jb winslowsvej 9b, Denmark, center of human development and aging,university of medicine and dentistry of new jersey,new jersey medical school,newark, United States, center of human development and aging,university of medicine and dentistry of new jersey,new jersey medical school,newark, United States, danish aging research center,universities of southern denmark,aarhus,and copenhagen,denmark,epidemiology,institute of public health,university of southern denmark,jb winslowsvej 9b,5000 odense c,denmark,danish twin registry,institute of public health,university of southern denmark,jb winslowsvej 9b,5000 odense c,denmark,department of clinical genetics,odense university hospital,5000 odense c,denmark,center for healthy aging,university of copenhagen, Denmark, danish aging research center,universities of southern denmark,aarhus,and copenhagen,denmark,section of social medicine,department of public health,university of copenhagen,p.o. box 2099,1014 copenhagen k,denmark,center for healthy aging,university of copenhagen,2200 copenhagen n,denmark,research center for prevention and health,capital region of denmark, Denmark, danish aging research center,universities of southern denmark,aarhus,and copenhagen,denmark,section of social medicine,department of public health,university of copenhagen,p.o. box 2099,1014 copenhagen k,denmark,center for healthy aging,university of copenhagen, Denmark
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Authors
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