Intraperitoneal Hydrocortisone Plus Bupivacaine Administration For Pain Relief After Laparoscopic Cholecystectomy, A Comparison With Bupivacaine Alone

Introduction: shorter hospital stay and less pain in comparison to open surgery considered to be major benefits forlaparoscopic cholecystectomy. we compared the effect of intraperitoneal hydrocortisone plus bupivacaine withbupivacaine alone on pain relief following laparoscopic cholecystectomy.methods: sixty two patients participated in this double-blind, randomized clinical trial. patients randomly receivedintraperitoneal instillation of either 100 mg bupivacaine in 250 ml normal saline (n=32) or 100 mg hydrocortisone plus 100mg bupivacaine in 250 ml normal saline (n=30) before insufflation of co2 into the peritoneum. abdominal and shoulderpain were evaluated using vas postoperatively. the patients were also followed for postoperative analgesic requirements,nausea and vomiting, and return of bowel function.we used independent student t-test and chi-square test and mann-whitney u tests with spss software to comparequantitative and qualitative variables, respectively. p value less than 0.05 was considered significant.results: sixty patients completed the study. patients in the hydrocortisone plus bupivacaine group had significantly lowerabdominal and shoulder pain scores (11.72 vs 8.92 in the bupivacaine and bupivacaine plus hydrocortisone group,respectively; p<0.01). the patients were similar regarding analgesic requirements .the patients were similar with respectto return of bowel function, nausea and vomiting. no adverse reaction was observed in either group.conclusions: intraperitoneal administrations of hydrocortisone plus bupivacaine can alleviate pain after laparoscopiccholecystectomy better than intraperitoneal bupivacaine alone.