investigating the therapeutic effects of selenium nanoparticles and tannic acid on postoperative peritoneal adhesion in rats

Introduction: developing effective and targeted therapeutic strategies for peritonitis and postoperative abdominal adhesions is essential to mitigate severe sequelae, including intestinal obstruction and infertility. therefore, this study aimed to evaluate the efficacy of intraperitoneally administered tannic acid and selenium nanoparticles (senps) in controlling experimental intraperitoneal adhesions in rats, leveraging their potential anti-inflammatory and antioxidant properties.methods: this experimental study included 30 adult male rats randomly divided into five equal groups: sham group (only laparotomy of the rats was performed without experimental adhesion induction), control group (experimental adhesion induction without any therapeutic intervention), senps group (intraperitoneal administration of senps after induction of peritoneal adhesion), tannic acid (ta) group (intraperitoneal administration of tannic acid after induction of peritoneal adhesions), and selenium nano tannic acid (senta) group (intraperitoneal administration of senps containing tannic acid after induction of peritoneal adhesion). seven days after the induction of peritoneal adhesions, abdominal adhesion rates and histopathological parameters were investigated and compared among the different groups using the kruskal-wallis test.results: abdominal adhesion formation was significantly reduced in the ta and senta treatment groups compared to controls (p = 0.01), while senps showed no significant improvement (p = 0.121). senta demonstrated superior efficacy among treatments with significantly lower adhesion scores than senps (p = 0.013) and no difference from ta (p = 0.65). histopathological analysis revealed that all treatments significantly reduced fibroplasia versus controls (p < 0.05). however, senta exhibited the most favorable tissue profile, showing significantly reduced inflammation, collagen deposition, and vascularization compared to the ta and senps groups (p < 0.05).conclusion: this leads to the conclusion that the simultaneous administration of tannic acid and senps, both of which have antioxidant and anti-inflammatory impacts, has been synergistically effective in controlling peritoneal adhesions.