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   prevalence of extended spectrum β-lactamase in klebsiella pneumonia isolates in a teaching hospital of zahedan city, iran  
   
نویسنده barakzahi mahbobeh ,hormozi bahman ,rashki ahmad ,rashki ghalehnoo zahra
منبع avicenna journal of clinical microbiology and infection - 2014 - دوره : 1 - شماره : 3 - صفحه:1 -4
چکیده    Extended-spectrum β-lactamase (esbl)-producing klebsiella pneumonia has become widespread in hospitals and is increasing in community settings. most of k. pneumonia that harbor these enzymes, display resistance to other unrelated antimicrobial agents and thus, often pose a therapeutic dilemma. this study was conducted to determine the prevalence of esbl-producing k. pneumonia in a major university hospital in zahedan, iran. the susceptibility of 83 k. pneumonia isolates to 12 antibiotics was assessed using kirby-bauer disc diffusion method. for the esbl phenotypic test, double-disk diffusion (dd) method was used. the highest resistance rates of the isolates were seen against cefixime (82%), cefotaxime (81%), ceftriaxone (73%), ceftazidime (72%), and azithromycin (60%), consecutively. the lowest resistance rates were observed against gentamicin (58%), tetracycline (59%), nalidixic acid (59%), and amikacin (63%), consecutively. esbls were found in 65% of k. pneumonia isolates. we found that 65% of k. pneumonia isolates produced esbl. therapeutic strategies to control infections should be carefully formulated in teaching hospitals. the high percentage of drug resistance in esbl-producing k. pneumonia suggests that routine detection of esbl by reliable laboratory methods is required.
کلیدواژه antibiotic resistance ,extended spectrum beta lactamase ,antimicrobial susceptibility ,klebsiella pneumonia
آدرس zabol university, department of biology, faculty of basic sciences, university of zabol, zabol, ir iran, ایران, zabol university, department of biology, faculty of basic sciences, university of zabol, zabol, ir iran, ایران, zabol university, department of physiopathology, faculty of veterinary medicine, university of zabol, zabol, ir iran, ایران, departments of microbiology and parasitology, faculty of medicine, zabol university of medical sciences, zabol, ir iran, departments of microbiology and parasitology, faculty of medicine, zabol university of medical sciences, zabol, ir iran, IR Iran
 
     
   
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