blood urea nitrogen and creatinine clinical prognosis in patients with severe coronavirus disease 19

Background: covid-19 is a new respiratory tract infection disease with an evolving understanding of its epidemiology and clinical appearances. kidney defects seem to be common in patients with covid-19. in addition, urea and creatinine (cr) levels often occur at the beginning or during the infection. this evidence shows that covid-19 also attacks the kidneys. the aim of this study was to evaluate changes in biochemical parameters associated with kidney function, including urea and cr, in patients with covid-19. methods: a retrospective analysis of the plasma cr and urea levels of 100 covid-19 patients with normal plasma cr and urea was conducted at the first clinical presentation of covid-19. results: blood urea nitrogen and cr levels increased in 35 (35%) out of 100 patients with covid-19 2–4 days after the onset of viral infection. the mean serum urea level and the mean cr concentration were 34.75±0.10, 37.64±0.32, 39.81±0.10, and 42.56±0.35 mg/dl, as well as 1.50±0.026, 1.51±0.016, 1.99±0.012, and 2.58±0.020 mg/dl, respectively, in the first clinical presentation and 2, 3, and 4 days after the onset of viral infection. conclusion: the analysis of cr and urea levels in patients at the onset of the disease and after 2–4 days revealed that impaired kidney function occurs in covid-19 patients, and it is one of the leading causes of death in these patients.