microrna155 may be an important part of human papilloma virus-related cancers

Background: micro-rnas (mirs) play several roles during infections with viruses. therefore, the roles of mir21 and mir155 in the induction of the viral-related cancers have been the focus of attention in several studies. high risk human papilloma viruses (hpvs) are the main factors negatively contributing to the induction of hpv-related cancers. this study aimed to evaluate the expression of mir21 and mir155 in the patients with hpv-high risk genotypes in order to explore the roles of the mirs in the induction of hpvrelated cancers. methods: in this study, 40 women infected with the high-risk hpv genotypes as well as 40 healthy controls were examined regarding the relative expression of mir21 and mir155 by adopting real-time polymerase chain reaction (pcr) technique. u6 was used for data normalization of mirnas. results: relative expressions of both mir21 and mir155 were significantly higher in the hpv-infected patients compared to those in non-infected women. conclusions: it was concluded that mir21 and mir155 may have played key roles in the induction of hpvrelated cancers among iranian patients