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   the antibacterial analysis of alcohol-free and alcohol-based chlorhexidine mouthwashes against oral bacteria  
   
نویسنده yousefimanesh hojatollah ,robati maryam ,piri atefeh ,khosravi boroujeni azardokht ,sirous mehrandokht
منبع avicenna journal of clinical microbiology and infection - 2022 - دوره : 9 - شماره : 1 - صفحه:16 -20
چکیده    Background: chlorhexidine (chx) is the gold standard chemical agent against oral pathogenic bacteria and is widely used for plaque/gingivitis control. the aim of the present study was to compare the effect of alcoholbased and alcohol-free chx mouthwashes on oral microorganisms. methods: in the present in vitro study, the standard strains of four microorganisms present in the oral cavity were prepared, including streptococcus mutans, streptococcus sanguinis, streptococcus salivarius, and lactobacillus casei. the serial dilutions of chx antimicrobial agents were obtained, and the level of minimum inhibitory concentration (mic) and minimum bactericidal concentration (mbc) was determined using the broth dilution method. finally, data were analyzed using the kruskal-wallis test, the mann-whitney u test, and spss-16. results: the mic values of 0.12% and 0.2% alcohol-free chx and 0.2% alcohol-based chx for s. mutans were 1.17, 0.48, and 0.24 μg/ml, respectively. the mbc values of 0.12% and 0.2% alcohol-free chx and 0.2% alcohol-based chx for s. mutans were 18.78, 7.81, and 7.81 μg/ml, respectively. the mic and mbc values of the tested chx mouthwashes for s. mutans were significant (p ≤ 0.05). conclusions: overall, the 0.2% alcohol-based chx mouthwash had the highest antibacterial activity against gram-positive bacteria.
کلیدواژه chlorhexidine ,mouthwashes ,minimum inhibitory concentration ,minimum bactericidal concentration ,alcohol
آدرس ahvaz jundishapur university of medical sciences, school of dentistry, department of periodontology, iran, ahvaz jundishapur university of medical sciences, school of dentistry, department of oral medicine, iran, ahvaz jundishapur university of medical sciences, school of dentistry, infectious and tropical diseases research center, health research institute, department of periodontology, iran, ahvaz jundishapur university of medical sciences, faculty of medicine, department of microbiology, iran, bushehr university of medical sciences, faculty of medicine, department of microbiology, iran
پست الکترونیکی sirous.m@ajums.ac.ir
 
     
   
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