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   evaluation of the antibacterial and investigation of the molecular docking of new derivatives of 1, 3, 4-oxadiazole as inhibitors of quorum sensing system in the human pathogen pseudomonas aeruginosa  
   
نویسنده ghameshlouei sepideh ,zarrabi ahrabi nakisa ,souldozi ali ,sarveahrabi yasin
منبع avicenna journal of clinical microbiology and infection - 2021 - دوره : 8 - شماره : 1 - صفحه:27 -33
چکیده    Background: oxadiazoles are a group of anti-inflammatory compounds that have a wide range of activity due to their higher efficacy. pseudomonas aeruginosa is an opportunistic pathogen and a major pathogen of nosocomial infections. this study aimed to evaluate the antibacterial and investigation of the molecular docking of new derivatives of 1, 3, 4-oxadiazole against p. aeruginosa, in vitro & in silico. materials and methods: four new derivatives were synthesized and added to our previous synthetic derivatives of 1, 3, 4-oxadiazole. the antibacterial activity of all derivatives was measured based on three standard species of p. aeruginosa using inhibition zone (iz) and minimum inhibitory concentration (mic) and minimum bactericidal concentration (mbc) methods. then, employing the computational design of the drug by the molecular docking method, the inhibitory effect of synthetic compounds on the lasr regulatory protein of p. aeruginosa quorum sensing system was investigated, which plays an important role in regulating the expression of pathogenic genes in bacteria. results: the chemical structures of new compounds were characterized by ir spectra and 1-hnmr. a variety of inhibitory effects were observed by the synthesized compounds – compound 4d and 4g, in particular. also, the inhibitory effect of these two compounds on the lasr regulatory protein under the control of the quorum sensing system in p. aeruginosa was demonstrated by molecular docking. conclusions: the results of this study showed that the two compounds containing the functional group of naphthalene and fluorophenyl have a significant effect on the inhibition of p. aeruginosa, as well as on the lasr protein of this bacterium.
کلیدواژه oxadiazoles ,antibacterial ,molecular docking ,fluorophenyl ,naphthalene
آدرس islamic azad university, central tehran branch, department of biology, iran, islamic azad university, central tehran branch, department of biology, iran, islamic azad university, urmia branch, department of chemistry, iran, islamic azad university, central tehran branch, department of biology, iran
پست الکترونیکی yasin.ahrabi2016@ gmail.com
 
     
   
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