transcriptional responses to cinnamaldehyde in mycobacterium tuberculosis

Background: tuberculosis (tb) is an infectious disease caused by mycobacterium tuberculosis. objectives: development of the drug resistance is becoming a threat to disease control, which underscores need for new agents targeting m. tuberculosis. materials and methods: in this study, analysis of gene expression was performed using real-time polymerase chain reaction (rt- pcr). results: results of the current study showed that the minimum inhibitory concentration value of cinnamaldehyde against m. tuberculosis was 200 µg/ml. moreover, rt-pcr data showed that a total of 25 genes were regulated by the cinnamaldehyde. of these, 12 genes were up-regulated, and 13 genes were down-regulated. conclusions: cinnamaldehyde is a pattern to expand the new anti-tb drugs, because the targets of the cinnamaldehyde are different from those of anti-tubercular agents.