Expression of Matrix Metalloproteinase-2 and -9 in Meningioma

Background: meningioma is one of the most common tumors of the central nervous system. it was shown that meningioma had upregulated expression of matrix metalloproteinases (mmps) that involved in cell growth, angiogenesis and metastasis. objectives: the aim of the study was the assessment of serum mmp2 and 9 levels in patients with different grades of meningioma. materials methods: the study included the number of 66 normal control and 101 patients with different grades of meningioma (42 cases of grade i, 38 grade ii and 21 grade iii). the serum samples was recruited between march 2013 and august 2017 at the departments of neurology and neurosurgery, in an academic hospital affiliated to guilan university of medical sciences, in the north of iran. mmp2 and 9 levels determined by enzyme linked immunosorbent assay (elisa). all data presented are expressed as mean plusmn;standard error of the mean (sem). statistical analysis was done using oneway anova by spss software, version: 24.0 and only values with p ≤0.05 were considered as significant results: we showed that the level of mmp2 and 9 in the serum samples of patients with meningioma was higher than in controls (p<0.01). we also showed that all serum samples from patients and controls, presented mmp2 and 9 expression, whereas, starting from grades i to iii meningioma, a significant increase of mmp2 and 9 protein expression was observed (p<0.05). conclusion: it is concluded that mmp2 and 9 are a constant composition of human serum. it is also concluded that mmp2 and 9 might be involved in the pathophysiology of meningioma and their detection in serum may be useful in classifying meningioma.