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   Tapering Oral Steroid Treatment After Iv Methylprednisolone Pulse Therapy in Demyelinating Optic Neuritis  
   
نویسنده Mohammadianinejad Ehsan ,Majidinasab Nastaran ,Nejati Adel ,Hatamian Hamidreza ,Mehramiri Asieh ,Sajedi Aidin ,Hesam Saeed
منبع Caspian Journal Of Neurological Sciences - 2018 - دوره : 4 - شماره : 12 - صفحه:1 -5
چکیده    Background: optic neuritis is an inflammation of the optic nerve. because of importance of vision for human, management of optic neuritis is an important issue in neurology.objectives: this study aimed at assessing the effect of oral steroid treatment after intravenous (iv) methylprednisolone therapy on demyelinating optic neuritis.materials methods: 60 patients with first episode of acute demyelinating optic neuritis who referred to a neurology clinic in an academic hospital in southwest of iran in 20152016 included in this randomized doubleblind clinical trial study (no: irct2015102724735n1). they were divided into two groups with (a) and without (b) tapering oral steroid treatment after iv methylprednisolone. visual acuity and color vision were measured before treatment, before oral tapering, 1 and 3 months after treatment. independent ttest in spss software version 20 was used to analyze the data. p<0.05 was considered as the level of significance.results: visual acuity in two groups did not have any significant difference in any time point of assessment (p>0.05).frequency of color vision abnormality in groups a and b were at baseline (53.3% vs. 56.6%) (p=0.796), before oral tapering (43.3% vs. 30%, p=0.284), 1 month after treatment (23.3% vs. 30%, p=0.559), 3 months after treatment (0% vs. 23%, p=0.011). conclusion: oral steroid treatment after iv methylprednisolone pulse therapy improves color vision after 3 months in patients with demyelinating optic neuritis but has no effect on visual acuity.
کلیدواژه Optic Neuritis ,Methylprednisolone ,Therapy
آدرس Ahvaz Jundishapur University Of Medical Sciences, Golestan Hospital, ایران, Ahvaz Jundishapur University Of Medical Sciences, Golestan Hospital, ایران, Ahvaz Jundishapur University Of Medical Sciences, Golestan Hospital, ایران, Guilan University Of Medical Sciences, Poursina Hospital, School Of Medicine, Department Of Neurology, ایران, Ahvaz Jundishapur University Of Medical Sciences, Golestan Hospital, ایران, Ahvaz Jundishapur University Of Medical Sciences, Golestan Hospital, ایران, Ahvaz Jundishapur University Of Medical Sciences, Golestan Hospital, ایران
 
     
   
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