effect of fluvoxamine on electrophysiological and behavioral alterations of rats with depression

Background: depression is a serious mental illness with symptoms such as worry, disturbed sleep and appetite, lack of interest or pleasure, and persistent sorrow.objectives: this study aims to assess the effect of fluvoxamine (flx) on behavioral and electrophysiological alterations of the posterior cingulate cortex (pcc) and the hippocampus in rats with depression.materials & methods: thirty-two albino rats (weighing 250-300 g) were divided into four groups; control (sham), chronic mild stress (cms), flx, and cms+flx. the cms was induced by applying different stressors for 3 weeks. intraperitoneal injection of flx (25 mg/kg) was performed daily for 14 days in the treatment group. depressive-like behaviors were assessed, and local field potentials (lfp) from the hippocampus and the pcc were recorded.results: flx effectively reduced depressive-like behaviors in rats with cms (p<0.05). additionally, depression-induced alterations in lfp were observed in the hippocampus and the pcc. depression reduced the power of delta and theta bands and increased the hippocampal low-gamma band power (p<0.05). in the pcc, depression increased the power of delta and low-gamma bands and reduced the power of the alpha band (p<0.05).conclusion: flx reduce depression-like behaviors in the animal model, possibly through affecting electrophysiological activity of the hippocampus and the pcc.