the relationship between bridging integrator 1 gene polymorphism and susceptibility to alzheimer’s disease

Background: alzheimer’s disease (ad) is the most common type of dementia. the role of genetic factors in ad development remains non-demonstrated. objectives: in this study, we aimed to investigate the association between one of the bin1 gene’s single-nucleotide polymorphisms(snp) rs744373 and late-onset alzheimer’s disease (load) in an iranian population in guilan province. materials & methods: in this case-control study, 110 patients with load and 110 unrelated healthy controls were recruited. polymerase chain reaction-restriction length polymorphism (pcr-rflp) was performed for genotyping the bin1 gene’s snp rs744373. electrophoresis was thereafter conducted using agarose gel and dna-safe stain, and the gels were visualized under an ultraviolet (uv) trans-illuminator. the allelic and genotypic frequencies were determined. results: the frequency of allele t (wild-type allele) in the control and the load groups was 70.9% (n=159) and 58.6% (n=129), respectively (p=0.007). the frequency of allele c in the load group (41.4%) (n=91) was significantly higher than that of the control group (29.1%) (n=64) (p=0.007). bin’s homozygous genotype (cc) frequency was significantly higher in the load group than in the control group (p=0.043). conclusion: the rs744373 snp of the bin1 gene is significantly associated with the risk of developing ad in the studied population.