Anticonvulsant Drugs and Severe Adverse Cutaneous Drug Reactions: A Longitudinal Observational Study

Background: severe adverse cutaneous reactions to drugs (sacrds) are skin eruptions due to drugs, which can cause morbidity and morbidity in patients.objectives: the aim of this study was to determine the offending drug/agents and clinical phenotypes of sacrds leading to admissions to the hospital.materials methods: we conducted a retrospective crosssectional study during one year (march 20122013) on patients admitted to the department of dermatology at razi hospital of rasht, iran. first, the clinical and drug history of all patients were collected. then, two dermatologists examined them and diagnosed drug eruptions according to the clinical types of adverse drug reactions included in the study. collected data were analyzed in spss v. 18 software by using chisquared test, fisher's exact test, and oneway anova. the significance level was set at p<0.05.results: fortysix patients were diagnosed with sacrds. the most common sacrds were toxic epidermal necrolysis/stevens johnson syndrome (tem/sjs) and drug reaction with eosinophilia and systemic symptom syndrome (dress) syndrome (30.5% and 2.1%, respectively). the most common culprit drugs were anticonvulsants (43.5%) and antibiotics (26.1%). peripheral blood eosinophilia was observed in 30.4% of patients.conclusion: anticonvulsants were the most common cause of acdrs, leading to the hospitalization of the patients.