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   Intravenous Thrombolysis, Time Window, Dosage, and Off-Label  
   
نویسنده Ghandehari Kavian ,Hatamian Hamidreza ,Shahedi Sharife ,Valipour Zahra ,Sobhani Mohammad Reza ,Salehian Hojat ,Nazemian Shokat ,Rezae Masumeh
منبع Caspian Journal Of Neurological Sciences - 2018 - دوره : 4 - شماره : 15 - صفحه:178 -183
چکیده    Despite the development of intravenous thrombolysis with tissue plasminogen activator (ivtpa) guidelines in each affiliated stroke center, protocol violations may be observed in each hospital with ivtpa facilities. an extensive search of scientific electronic databases including pubmed, ovid, index medicus, index copernicus, google, isi, and scopus was performed with keywords of thrombolysis, off-label, out of protocol, violation, time window, dose, tpa, and stroke terminated on 01 may 2018. safety and functional outcomes are less favorable beyond three hours; however, the wider time window until 4.5 hours is recommended. lower dose of alteplase (0.6 mg/kg) is approved in japan. the proposed dose of tpa in iranian population is similar to that of the japanese. overall, the outcomes in patients treated with offlabel ivtpa or protocol violation were better than those of the controls based on registry data. there is little disagreement about time window of ivtpa. the dose of 0.6 mg/kg is used in some asian countries with similar therapeutic results.
کلیدواژه Stroke ,Tissue Plasminogen Activator
آدرس Mashhad University Of Medical Sciences, School Of Medicine, Department Of Neurology, ایران, Guilan University Of Medical Sciences, Poursina Hospital, Department Of Neurology, ایران, Mashhad University Of Medical Sciences, School Of Medicine, ایران, Mashhad University Of Medical Sciences, School Of Medicine, ایران, Mashhad University Of Medical Sciences, School Of Medicine, Department Of Neurology, ایران, Mashhad University Of Medical Sciences, School Of Medicine, Department Of Neurology, ایران, Mashhad University Of Medical Sciences, School Of Medicine, Department Of Neurology, ایران, Mashhad University Of Medical Sciences, School Of Medicine, Department Of Neurology, ایران
 
     
   
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