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   Gene Expression of Cd226 and Its Serum Levels in Patients With Multiple Sclerosis  
   
نویسنده Alsahebfosoul Fereshteh ,Rahimpourkoldeh Shokofeh ,Eskandari Nahid ,Shaygannejad Vahid ,Ganjalikhani Hakemi Mazdak ,Dabiri Arezo ,Jafarnia Morteza ,Mirmossayeb Omid
منبع Caspian Journal Of Neurological Sciences - 2018 - دوره : 4 - شماره : 14 - صفحه:91 -97
چکیده    Background: recent studies have found some genetic variants as a risk factor for autoimmune diseases such as multiple sclerosis (ms). cluster of differentiation 226 (cd226) is one of the risk factors for ms. objectives: the present study aimed to evaluate the gene expression of cd226, and its protein serum level in peripheral blood samples of ms patients and healthy individuals.materials methods: thirty individuals with ms and 30 healthy individuals, as controls, referred to kashani hospital of isfahan, iran. cd226 expression at the transcript level and serum protein levels were measured by quantitative realtime polymerase chain reaction and enzymelinked immunosorbent assays, respectively. statistical analyses were performed by shapirowilk test and nonparametric tests in spss. results: the present study showed no significant differences in the gene expression of cd226 (p=0.341). the mean serum protein level of cd226 was not different between the patients and the controls (p=0.978).conclusion: overall, cd226 expression has no diagnostic usefulness in ms at either the transcript or serum level. keywords: multiple sclerosis, demyelinating diseases, gene expression, cluster of differentiation 226 (cd226) antigen
کلیدواژه Multiple Sclerosis ,Demyelinating Diseases ,Gene Expression ,Cluster Of Differentiation 226 (Cd226) Antigen
آدرس Isfahan University Of Medical Sciences, School Of Medicine, Isfahan Neurosciences Research Center, Alzahra Hospital, Department Of Immunology, Department Of Neurology, ایران, Isfahan University Of Medical Sciences, School Of Medicine, Department Of Immunology, ایران, Isfahan University Of Medical Sciences, School Of Medicine, Department Of Immunology, ایران, Isfahan University Of Medical Sciences, Isfahan Neurosciences Research Center, Alzahra Hospital, Department Of Neurology, ایران, Isfahan University Of Medical Sciences, School Of Medicine, Department Of Immunology, ایران, Shahid Sadoughi University Of Medical Sciences, International Campus, Department Of Immunology, ایران, Isfahan University Of Medical Sciences, School Of Medicine, Department Of Immunology, ایران, Isfahan University Of Medical Sciences, Isfahan Neurosciences Research Center, Alzahra Hospital, Department Of Neurology, ایران
پست الکترونیکی mirmossayyeb@gmail.com
 
     
   
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