|
|
B Cell Therapy To Treat An Axonal Neuropathy in Mixed Connective Tissue Disease
|
|
|
|
|
نویسنده
|
David Lyman
|
منبع
|
Caspian Journal Of Neurological Sciences - 2017 - دوره : 3 - شماره : 8 - صفحه:46 -53
|
|
|
چکیده
|
The b cell is a vital contributor to humoral immunity. the b cell-specific antigen cd20 is expressed during b cell development, starting at the pre-b cell level and persists through b cell differentiation, but is lost during terminal differentiation to plasma cells. rituximab is a monoclonal antibody that destroys both normal and malignant b cells that have cd20 on their surfaces and is therefore used to treat diseases characterized by excessive b cells, overactive b cells, or dysfunctional b cells. the connective tissue diseases and vasculitis mediated by b cell may cause various disorders of the peripheral nervous system especially axonal neuropathy. b cell–directed therapies may represent a promising new treatment for autoimmune axonal neuropathies.
|
کلیدواژه
|
B Cell; Therapy; Giant Axonal Neuropathy; Mixed Connective Tissue Disease
|
آدرس
|
University Of Tennessee, Department Of Family Medicine, Usa
|
پست الکترونیکی
|
dlymanmdmph@gmail.com
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|