lupus erythematosus- bullous pemphigoid overlap-tale of a rare co-existence

Introduction: systemic lupus erythematosus (sle) is an autoimmune connective tissue disease, typically encountered as an isolated condition or, less frequently, in association with other autoimmune blistering diseases. herein, we report a rare case of overlap between lupus erythematosus and bullous pemphigoid. very few cases of this co-existence have been documented worldwide. case presentation: a young woman presented with intense itching, photosensitivity, and vesiculobullous lesions on the skin and oral mucous membranes, with histological features indicative of bullous pemphigoid (bp) and a positive serological test for lupus erythematosus (le). there was marked improvement with the administration of dapsone and antimalarials. conclusions: vesiculobullous lesions in le are a rare cutaneous manifestation of cutaneous and/or systemic le, presenting with variable and atypical features that can lead to diagnostic difficulty and delay. the diagnosis and management of le-associated vesiculobullous diseases remain challenging due to the similarities in clinical and immunohistopathological features.