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go/tio2 hybrid nanoparticles as new photosensitizers in photodynamic therapy of a375 melanoma cancer cells
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نویسنده
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karbalaei atieh ,mohammadalipour zahra ,rahmati marveh ,khataee alireza ,moosavi mohammad amin
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منبع
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journal of skin and stem cell - 2017 - دوره : 4 - شماره : 1 - صفحه:1 -5
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چکیده
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Photodynamic therapy (pdt) by nanoparticles (nps) has been proposed as a new emerging therapeutic approach for the treatment of melanoma. in this study, the researchers investigate potential of photodynamic graphene oxide (go)/tio2 hybrid (got) nps as new photosensitizers (pss) in a375 melanoma cancer cell line. the results showed that while different concentrations of got nps (1 - 100 g/ml) were inert, their irradiation with visible-light induced growth arrest and cell death in a375 cells in a dose-despondent manner. these anti-cancer effects were accompanied by significant morphological changes, suggesting got nps have a potential for further evaluation as new generation of pss for cancer therapy.
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کلیدواژه
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a375 cells ,graphene oxide/titanium dioxide ,melanoma ,photodynamic therapy
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آدرس
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national institute for genetic engineering and biotechnology, institute of medical biotechnology, department of molecular medicine, ایران, national institute for genetic engineering and biotechnology, institute of medical biotechnology, department of molecular medicine, ایران, tehran university of medical sciences, cancer biology research canter, ایران, university of tabriz, faculty of chemistry, research laboratory of advancedwater andwastewater treatment processes, department of applied chemistry, ایران, national institute for genetic engineering and biotechnology, institute of medical biotechnology, department of molecular medicine, ایران
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پست الکترونیکی
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a-moosavi@nigeb.ac.ir
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Authors
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