efficacy of oral pregabalin premedication as an adjuvant to fentanyl in patients undergoing major surgeries under general anesthesia: an observational study

Intubation and laryngoscopy may raise blood pressure and heart rate unnecessarily. to investigate the effect of pregabalin premedication on hemodynamic responses to laryngoscopy and intubation. methods: a prospective observational study was carried out in academic year december 2013 to july 2015 on 60 asa physical status i or ii patients undergoing elective surgery under general anesthesia at tertiary care hospital. 60 patients were divided into two equal groups of 30 each who received either fentanyl (group a) or oral pregabalin 150 mg (group b) 1 hour prior to surgery. pulse rate, systoli and diastolic blood pressure were recorded preoperative, and 0,1,3,5 and 10 minutes after induction. confidentiality of the subject was maintained. descriptive and inferential statistics for quantitative and categorical variables were analysed using ibm spss version 22. results: sbp, dbp, and map rise during laryngoscopy and during intubation in a similar way in both groups at laryngoscopy (bl) and at 1 and 3 minutes following laryngoscopy before levelling off after 10 minutes in both groups. at baseline and one minute after laryngoscopy, hr increased in both groups. at 3 min, 5 min, and 10 min following laryngoscopy, the rise was reduced in the fl group, however the differences were statistically significant, p 0.005. conclusion: oral pregabalin premedication at a dose of 150 mg one hour prior to surgery attenuates pressor response associated with laryngoscopy and endotracheal intubation.