effect of ketamine-sufentanil and ketaminemidazolam to induce sedation and analgesia in pediatric with lumbar puncture or bone marrow aspiration

Background: the combination of sedative and analgesic drugs has a favorable effect on pain management and sedation during painful procedures in pediatrics. therefore, our aim was to compare the effect of sedation and analgesia of ketamine-sufentanil and ketamine-midazolam in painful procedures in children with blood malignancies. methos: this double-blind, clinical trial was performed on 82 children with malignancy who had indication of painful diagnostic intervention; patients were randomly divided into two groups of ketamine-sufentanil (ks) and ketamine -midazolam (km). in ks group, sufentanil 0.5mcg/ kg and ketamine 1mg/ kg and in the km group, ketamine 1mg/ kg, and midazolam 0.1mg/ kg bolus were prescribed. in either group, hemodynamic indicators of sedation, side effects, duration of effectiveness were recorded. data were analyzed using spss 20. results: sedation based on ramsay sedation score was not significantly different between the two groups (p= 0.39). the average recovery time in the midazolam-ketamine group was higher (p-value= 0.076).conclution: the combination of ketamine-sufentanil and ketamine-midazolam was effective in sedation and analgesia in bone marrow aspiration and lumber puncture; side effects were however, lower in ketamine-midazolam group.