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association of the promoter methylation of mitochondrial transcription factor a with susceptibility to metabolic syndrome
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نویسنده
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hashemi mohammad ,rezaei hamzeh ,ali kaykhaei mahmoud ,taheri mohsen
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منبع
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gene cell tissue - 2014 - دوره : 1 - شماره : 1 - صفحه:1 -4
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چکیده
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It has been proposed that the patients with mitochondrial diseases usually manifest systemic metabolic disorders. the metabolic syndrome (mes), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type 2 diabetes (t2d) and cardiovascular disease. the aim of study was to investigate the possible association between promoter methylation of mitochondrial transcription factor a (tfam) and mes. dna was extracted from peripheral blood of 151 patients with and 149 without mes. tfam promoter methylation was evaluated by a nested methylation-specific pcr (nested msp). no association was found between tfam promoter methylation and mes. the present study suggests that the tfam promoter methylation is not associated with risk of mes.
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کلیدواژه
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metabolic syndrome x ,mitochondrial transcription factor a ,diabetes mellitus ,type 2 dm
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آدرس
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cellular and molecular research center, zahedan university of medical sciences, zahedan, ir iran, cellular and molecular research center, zahedan university of medical sciences, zahedan, ir iran, IR Iran, department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran, department of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, ir iran, IR Iran, department of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, ir iran, department of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, ir iran, IR Iran, genetics of non-communicable disease research center, zahedan university of medical sciences, zahedan, ir iran, genetics of non-communicable disease research center, zahedan university of medical sciences, zahedan, ir iran, IR Iran
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Authors
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