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absence of immune response as a sign of tissue tolerance in small-cell lung cancer
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نویسنده
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manenti antonio ,roncati luca ,sighinolfi pamela ,barbolini giuseppe
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منبع
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gene cell tissue - 2014 - دوره : 1 - شماره : 2 - صفحه:1 -3
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چکیده
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The attention of the scientific community has been recently focused on the role of tumor-infiltrating lymphocytes in non-small-cell cancer and there is a convergence of results, supporting a direct proportionality between lymphocytic infiltrate and good prognosis. the aim of our research was to investigate the immune response around and inside the small-cell lung neoplastic tissue and its related neo-lymphangiogenesis in a group of 20 patients. we have examined 20 bioptic samples of small cell lung cancer, obtained from 18 men and two women, aged 56-74 years old. besides hematoxylin-eosin staining, immunohistochemistry for neuroendocrine markers (cd56, chromogranin) and d2-40 was performed following the standard protocols. our histological analysis, in all cases, has emerged the absence of an immune response supported by an adequate neo-lymphangiogenesis inside the neoplasia. the absence of an immune response is interpreted as a sign of tissue tolerance and host acceptance towards the cancer, in favor of the cancer metastatic spread. the development of a paraneoplastic syndrome can be considered a biochemical proof of this tissue compatibility.
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کلیدواژه
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small cell lung carcinoma ,antigens ,cd56 ,chromogranins ,monoclonal antibody d2-40 ,paraneoplastic syndrome
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آدرس
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department of medical and surgical sciences, section of surgery, university of modena and reggio emilia, modena, italy, department of medical and surgical sciences, section of surgery, university of modena and reggio emilia, modena, italy, Italy, department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy, department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy, Italy, department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy, department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy, Italy, department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy, department of diagnostic and clinical medicine and public health, section of pathology, university of modena and reggio emilia, modena, italy, Italy
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Authors
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