analysis of ctla-4 (+49a/g) gene polymorphism and the risk of tuberculosis in southeast of iran

Tuberculosis (tb) is an acute or chronic bacterial infection caused by mycobacterium tuberculosis. it primarily affects the lungs, but may spread to other organs (extra-pulmonary tb). studies have shown that genetic predisposition can decrease the persistence and growth of m. tuberculosis. the current study highlights the effect of ctla-4 (+49a/g) gene polymorphism on the risk of tb. this case-controlled study used tetra-primer amplification refractory mutation system-polymerase chain reaction (arms-pcr) to analyze thectla-4 (+49a/g) gene polymorphism in 100 patients with tb and 91 healthy individuals. data analysis indicated that the frequencies of aa, ag and gg genotypes were 42%, 38%, and 20% in patients with tb and 43%, 47%, 1% in the control subjects, respectively. the gg genotype of ctla-4 (+49a/g) showed a significantly increased risk of disease (or = 20.48; 2.63-159.60) the results revealed a significant relationship between the gg genotype of ctla-4 and the increased risk of tb.