interactive effect of grape seed nanoparticle extract and resistance training on antioxidant system function in myocardial infarction rat model

Background: the use of herbal supplements and exercise to treat chronic diseases and metabolic disorders is a common practice. objectives: this study aimed to investigate the effect of eight weeks of grape seed nanoparticle extract and resistance training on sod, mda, and nrf-1expression in the myocardial infarction rat model. methods: in this experimental trial, 25 wistar rats were randomly divided into five groups: (1) control, (2) mi, (3) rt + mi, (4) gs + mi, and (5) rt + mi + gs. resistance training was performed for eight weeks and five sessions per week. also, 150 mg of grape seed extract was gavage daily. one-way analysis of variance and the tukey test was used to compare groups at the p ≤ 0.05. results: resistance training with grape seed significantly increased nrf-1gene expression (p = 0.001) and sod (p = 0.01) compared to mi grope. while resistance training with grape seed significantly reduced mda compared to the mi group (p = 0.01). conclusions: it seems that resistance training with grape seed consumption has a more positive effect on increasing nrf-1gene expression and improving the antioxidant system in the heart tissues of rats with myocardial infarction rather than using each alone.