the effect of two types of training programs on the expression of trkb, bax and bcl-2 genes in male rats after induction of cerebral ischemia

Background: physical activity and dynamic lifestyle play an important role in the prevention and treatment of some common neurological diseases. onevaluable approach to increasing healthandreducing braindamageis to performanexerciseandphysical activity. objectives: the aim of the present study was to investigate the effect of exercise pre-training on the intervening factors and complications of cerebral ischemia. methods: in this study, forty wistar rats were randomly divided into four groups, including (1) endurance training, (2) endurancecognitive training, (3) ischemia, and (4) control. the training was performed for 3 weeks. after the last training session, the rats had to undergo cerebral ischemia. the ischemia was induced by occlusion of both common carotid arteries for 30 min. real-time pcr method was used to measure the expression level of trkb, bax, and bcl-2 genes. results: the levels of trkb gene expression were significantly increased in the endurance training and endurance-cognitive training groups compared to the ischemia and control groups (p < 0.05). there was a significant increase in the levels of bcl-2 gene expression in the endurance training group compared to the ischemia group as well as the endurance-cognitive group compared to the ischemia and control groups (p < 0.05). also, the levels of bax gene expression in the endurance training and endurance-cognitive groups were significantly lower than the control group (p < 0.05). conclusions: this study showed that exercise as a preconditioning stimulus has neuroprotective effects against cerebral ischemia.