evaluation of 40-bp insertion/deletion polymorphism of mdm2 and the risk of childhood acute lymphoblastic leukemia

Background: the human murine double minute 2 (mdm2), an oncoprotein, is the major negative regulator of p53. objectives: the purpose of this study was to evaluate the impact of 40bp insertion/deletion (ins/del) polymorphism in the promoter of mdm2 and vulnerability to childhood acute lymphocytic leukemia (all) in a sample of iranian population. patients and methods: this casecontrol study was performed on 75 children diagnosed with all and 115 healthy children. the 40bp ins/del variant was determined by using the polymerase chain reaction method. results: our findings showed that neither the overall chisquare comparison of cases and control subjects (x² = 1.13, p = 0.569) nor the logistic regression analysis (codominant: or = 1.29, 95% ci = 0.592.14, p = 0.745, ins/del vs. ins/ins; or = 1.59, 95% ci = 0.59-3.77, p = 0.372, del/del vs. ins/ins, dominant: or = 1.25, 95% ci = 0.69-2.23, p = 0.552, ins/del + del/del vs. ins/ins and recessive: or = 1.51, 95% ci = 0.67-3.43, p = 0.395, del/del vs. ins/ins + ins/del) indicated any association between mdm2 ins/del and all in our population. conclusions: our findings indicated that mdm2 40bp ins/del polymorphism was not associated with all in our iranian population. further studies with larger sample sizes and diverse ethnicities are required to verify our findings.