investigation of clinical potential roles of js-2 gene in pathogenesis of colorectal cancer

Background: colorectal cancer (crc) is the third prevalent adenocarcinoma type with a high mortality rate worldwide. the js-2 is a novel gene, which first was described in esophageal squamous cell carcinoma (escc). to date, several studies have investigated the role of js-2 in the pathogenesis of crc. objectives: the purpose of our survey was to assess the js-2 gene expression level in subjects with crc in the iranian population. methods: the current case-control study was conducted on one hundred fresh tissues, consisting of 50 cancerous colorectal adenocarcinomas and 50 adjacent non-cancerous tissues. the relative js-2 gene expression level was assessed using quantitative real-time polymerase chain reaction (qreal-time pcr) method. results: our findings showed that the js-2 gene was significantly over-expressed in cancerous tissues compared with the adjacent non-cancerous tissues (p = 0.037). in addition, overexpression of js-2 was significantly related to the tumor differentiation (p = 0.047) and tumor stage (p = 0.036). conclusions: the results suggested that the js-2 gene played an important role in the progression of crc and may be applied as a novel prognostic biomarker in patients with crc.