|
|
|
|
effect of levisticum officinale hydroalcoholic extract on du-145 and pc-3 prostate cancer cell lines
|
|
|
|
|
|
|
|
نویسنده
|
sargazi saman ,saravani ramin ,galavi hamid reza ,mollashahee-kohkan fatemeh
|
|
منبع
|
gene cell tissue - 2017 - دوره : 4 - شماره : 4 - صفحه:1 -4
|
|
چکیده
|
Levisticum officinale contains a variety of components used for its medicinal properties in traditional medicine. the previous studies showed that it had an anti-cancer effect on cell lines. the current study aims to evaluate the cytotoxic potential of levisticum officinale hydroalcoholic extract (lohe) on du-145 and pc-3 human advanced prostate cancer cell lines. the anti-proliferative activity of lohe was evaluated using the mtt assay. the results of mtt showed that the ic50 of du-145 and pc-3 were 500 g/ml and 400 g/ml of lohe, respectively, following 24 hours treatment. this study found that the hydroalcoholic extract of levisticum officinale had beneficial cell death inducing effects on both the pc3 and du145 human prostate carcinoma cell lines in time- and concentrationdependent fashion. hence, lohe may have remarkable potential for uses as new natural anticancer agent.
|
|
کلیدواژه
|
prostate cancer ,cytotoxic effects ,cell death ,levisticum officinale
|
|
آدرس
|
shahid sadoughi university of medical sciences, school of medicine, department of clinical biochemistry, ایران, zahedan university of medical sciences, school of medicine, cellular and molecular research center, department of clinical biochemistry, ایران, zahedan university of medical sciences, school of medicine, cellular and molecular research center, department of clinical biochemistry, ایران, zahedan university of medical sciences, school of medicine, cellular and molecular research center, department of clinical biochemistry, ایران
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|