association of statin therapy on clinical outcomes in covid-19 patients: an updated systematic review and meta-analysis on all related evidences

Introduction: statins is a class of lipid-lowering drugs and our previous investigations showed that statins have antiviral effects and have a wound healing effect in the lung. this systematic review and meta-analysis aimed to evaluate the effects of statin therapy on mortality and clinical outcomes in covid-19 patients. methods: a comprehensive search was conducted in international databases, including medline, scopus, web of science, and embase from december 1, 2019 until january 26, 2022 without any restriction in language. the random-effects model was used to estimate the pooled odds ratio (or). results: the statin therapy overally was associated with decrease in odds of ventilation [pooled or (95% ci): 0.85 (0.70 to 0.99)] and mortality [pooled or (95% ci): 0.73 (0.66 to 0.81)] but had no effects on the icu admission [pooled or (95% ci): 0.93 (0.77 to 1.12)], oxygen therapy [pooled or (95% ci): 0.85 (0.70 to 0.99)], recovery [pooled or (95% ci): 1.85 (0.35 to 9.92)], kidney failure [pooled or (95% ci): 1.01 (0.73 to 1.40)], hospitalization [pooled or (95% ci): 1.45 (0.88 to 2.36)], asymptomatic disease [pooled or (95% ci): 1.33 (0.24 to 7.44)], and ards [pooled or (95% ci): 1.15 (0.88 to 1.49)]. conclusion: the present meta-analysis showed that statin therapy was associated with a reduced risk of mortality and ventilation in patients with covid-19 but had no effects on other clinical outcomes.