>
Fa   |   Ar   |   En
   Attempts and Outcomes of Liquisolid Technology: An Updated Chronological Compilation of Innovative Ideas and Adjuvants in the Field  
   
نویسنده Sharma Vijay ,Pathak Kamla
منبع Pharmaceutical And Biomedical Research - 2016 - دوره : 2 - شماره : 4 - صفحه:1 -21
چکیده    It has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. in order to improve the bioavailability, the release behavior of such drugs should be improved. although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced manufacturing operations that includes multiple and tedious steps. the liquisolid technology or powder solution technology is a promising technique for modifying the release characteristics of active pharmaceutical ingredients. as the liquisolid technology uses similar production processes as followed to develop a conventional tablet, but this technology to improve the release rate of poorly water soluble drugs is simple and cost effective the core concept of the technique involves, liquids such as solution/dispersion of poorly soluble drugs in a nonvolatile solvent that is transformed into free flowing and desirable compression characteristics. to develop a fastrelease liquisolid formulation, high amount of liquid vehicle is required while more effective tableting excipients with high liquid adsorption are needed to reduce the weight of the tablet. simultaneously, this technology also has the capability to sustain the drug release and allow the development of sustained release formulation with desirable release kinetics. the present work deals with the chronological compilation and briefing of all the reported researches which involved the concept of underlined technology by the use of common as well as novel excipients to modify the release behavior of therapeutically active compounds.
کلیدواژه Liquisolid Technology ,Non-Volatile Solvent ,Carrier Material ,Coating Material ,Dissolution Enhancement ,Liquisolid Compact ,Sustained Release
آدرس Rajiv Academy For Pharmacy, Department Of Pharmaceutics, India, Pharmacy College Saifai, Department Of Pharmaceutics, India
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved