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   Amelioration of Methamphetamine Cardiotoxicity By Propofol  
   
نویسنده Shaki Fatemeh ,Koohsari Motahareh
منبع Pharmaceutical And Biomedical Research - 2015 - دوره : 1 - شماره : 3 - صفحه:37 -46
چکیده    Methamphetamine (met) is a stimulant and one of the most abused drugs inworldwide. met could cause several organ toxicity such as cardiotoxicity. oxidativestress has been proposed as the main mechanism for met toxicity. propofol as asedative-hypnotic agent has antioxidant property. in this study, we used propofol forattenuating of met-induced cardiotoxicity in rats. the groups (six rats in each group)were as follows: control, met (5 mg/kg ip) and treated groups that were receivedpropofol (5, 10 and 20 mg/kg, ip) and vitamin e, 30 min before met administration.after 24 hours, animals were killed, and heart tissue and blood were separated. metcardiotoxicity was assessed by the evaluation of the levels of lactic acid dehydrogenase(ldh) and creatine phosphokinase (cpk) as cardiac marker enzymes. on the otherhand, oxidative stress markers such as reactive oxygen species (ros), lipidperoxidation (lpo), glutathione (gsh) and protein carbonyl were measured in hearttissue. treatment with propofol significantly decreased the cardiac marker enzymeslevel which increased in met-treated group. propofol significantly inhibited the rosformation and protected the cardiac tissue against lpo. propofol also significantlyprevented met induced gsh oxidation in cardiac tissue. protein carbonyl level wasincreased after met exposure, but was significantly decreased with propofol pretreatment.this study showed that propofol prevented met-induced cardiotoxicity viainhibition of oxidative stress damage. therefore, the efficacy of this antioxidant couldbe evaluated for the treatment of met toxicity situation.
کلیدواژه Methamphetamine ,Cardiotoxicity ,Propofol ,Oxidative Stress ,Cardiac Enzyme
آدرس Mazandaran University Of Medical Sciences, Faculty Of Pharmacy, Department Of Toxicology And Pharmacology, ایران, Mazandaran University Of Medical Sciences, Research Student Committee, ایران
 
     
   
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