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   Atp Depletion and Oxidative Damage of Hepatic Cells Following Acute Exposure To Malathion in Rat: Beneficial Role of Porphyrin–Fullerene Nanoparticles Carrying Magnetic Magnesium  
   
نویسنده Bakhtiarian Azam ,Abdollahi Mohammad ,Rezayat Mahdi ,Rezayat Mahdi ,Rezayat Mahdi ,Mohammadi Hamid Reza ,Mohammadi Hamid Reza
منبع Pharmaceutical And Biomedical Research - 2015 - دوره : 1 - شماره : 2 - صفحه:10 -19
چکیده    The objective of the present study was to investigate the role of nanocarrier of magnetic isotope of 25mg^2+ (pmc16) in liver toxicity, atp content and oxidative stress due to malathion (mal) exposure. pmc16 nanoparticle were administered in different doses (0.05, 0.1 and 0.2 ld50) intravenously (iv) 40 minutes after a single mal (0.25 ld50= 207 mg/kg) intraperitoneal (ip) injection as a complement to standard therapy of pralidoxime (pam) and atropine (at). mgso4 was used as another supplement for comparison with pmc16. atp/adp ratio, antioxidant enzymes including catalase (cat), glutathione peroxidase (gpx), superoxide dismutase (sod), and oxidative stress biomarker including lipid peroxidation (lpo) were evaluated in liver tissue cells. results indicated that after mal administration, adp/atp ratio had a significant increase in liver tissues in comparison with control but this ratio was improved using various doses of pmc16. lpo was significantly decreased at all doses of pmc16 and mgso4 when compared with malexposed group. sod and cat activities significantly were increased in maltreated group as compared to saline group. sod was reduced by all doses of pmc16 and cat activity was decreased in pmc160.1 group. these results lead us to conclude that pmc16 and mgso4 are so useful for protection against malinduced liver toxicity, atp depletion and oxidative damages.
کلیدواژه Organophosphate ,Malathion ,Magnesium ,Nanocarrier ,Adenosine Triphosphate ,Oxidative Stress
آدرس Tehran University Of Medical Sciences Tums, School Of Medicine, Department Of Pharmacology, ایران, Tehran University Of Medical Sciences Tums, Faculty Of Pharmacy, Pharmaceutical Sciences Research Center, ایران, Tehran University Of Medical Sciences Tums, School Of Medicine, Department Of Pharmacology, ایران. Tehran University Of Medical Sciences Tums, Faculty Of Advanced Sciences And Technology In Medicine, ایران. Islamic Azad University, Pharmaceutical Science Branch, ایران, Tehran University Of Medical Sciences Tums, School Of Medicine, Department Of Pharmacology, ایران. Tehran University Of Medical Sciences Tums, Faculty Of Advanced Sciences And Technology In Medicine, ایران. Islamic Azad University, Pharmaceutical Science Branch, ایران, Tehran University Of Medical Sciences Tums, School Of Medicine, Department Of Pharmacology, ایران. Tehran University Of Medical Sciences Tums, Faculty Of Advanced Sciences And Technology In Medicine, ایران. Islamic Azad University, Pharmaceutical Science Branch, ایران, Mazandaran University Of Medical Sciences, Pharmacutical Science Research Center, Hemoglobinopathy Institute, ایران. Mazandaran University Of Medical Sciences, Faculty Of Pharmacy, Department Of Toxicology And Pharmacology, ایران, Mazandaran University Of Medical Sciences, Pharmacutical Science Research Center, Hemoglobinopathy Institute, ایران. Mazandaran University Of Medical Sciences, Faculty Of Pharmacy, Department Of Toxicology And Pharmacology, ایران
 
     
   
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